8:00 am – 8:30 am

Opening Remarks

8:30 am – 9:50 am

Session I

CNS response in NeuroAIDS

Howard Gendelman
(Plenary Speaker)

Anti-retroviral nanoformulations for enhancing CNS drug delivery

Howard Fox
(Plenary Speaker)

Multifaceted response to SIV in the brain

Linda Chang

Bioimaging and CNS responses to HIV-1 infection

Georgette Kanmogne

STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier

9:50 am – 10:15 am

Coffee Break

10:15 am – 11:50 am

Session II

Clinical parameters & co-pathogens in NeuroAIDS

Vincent Soriano
(Plenary Speaker)

Neurologic disorders in patients co-infected with HIV and HTLVs

Christina Marra
(Plenary Speaker)

Syphilis and HIV: Are they copathogens?

Bruce Shiramizu

Level of HIV-1 DNA in peripheral blood mononuclear cells (PBMCs) increases with severity of neurocognitive dysfunction

Paola Cinque

Cerebrospinal fluid (CSF) soluble urokinase plasminogen activator (uPA) receptor (suPAR) in AIDS Dementia Complex, and its relationships with other uPA, virological, immune activation, and neuronal CSF Markers

Valerie Wojna

Oxidative stress markers may serve as a biomarker for the progression of HIV-associated cognitive impairment in women

11:50 am – 12:25 pm

Paradigm Builder Lectureship
Peter Palese

Influenza virus pandemics: Past and future

12:25 pm – 2:15 pm

Lunch

12:30 pm – 2:00 pm

Breakout Session I

NeuroAIDS - Emerging issues in NeuroAIDS: Preclinical models to clinical studies

Francesca Peruzzi

Inhibition of synaptic proteins by HIV-1 Tat involves the activity of microRNA

Sanjay Maggirwar

Inhibition of mixed lineage kinase (MLK)-3 breaks HIV-1 neurotoxin-induced feedback loop between platelet activation and microglial stimulation

Dianne Langford

Novel expression of PINCH in the CNS and its potential as a biomarker for HIV-associated neurodegenerative processes

Karl Kasischke

Multicompartment multiphoton NADH imaging: A neuroimaging method for the direct study of non-neural and neuronal pathologies in rodent models of neuroAIDS?

Beau Ances

Cerebral Blood Flow (CBF) and cerebral metabolic rate of oxygen consumption (CMRO2) are elevated in both early and chronically infected HIV+ patients compared to seronegative controls using quantitative functional magnetic resonance imaging (qfMRI)

Olimpia Meucci

Alteration of neuronal CXCR4 function by in vivo/in vitro opiates treatments and its role in neuronal survival and HIV neuropathogenesis

2:15 pm – 3:35 pm

Session III

Drugs of abuse, aging, and other comorbidities in NeuroAIDS

Igor Grant
(Plenary Speaker)

Multifaceted influences on presentation of NeuroAIDS

Cristian Achim
(Plenary Speaker)

Abnormal protein aggregation in the brains of long-term surviving HIV patients in the HAART era

Stanley Schwartz

Opiates exacerbate HIV-1 neurotoxicity via DARPP-32 regulation of NMDA receptors

Michael Taffe

Nonhuman primate models of drug abuse and AIDS

3:35 pm – 4:00 pm

Coffee Break

4:00 pm – 5:30 pm

Investigators in Training I

Jaclyn Nicolai

Activation of the cell cycle protein CDC2 may cause calcium dysregulation in postmitotic neurons contributing to HIV-induced excitotoxicity and neuronal cell death

Tobias Derfuss

T-cell infiltrates in HSV-1 latently infected human geniculate ganglia

Rachel Williams

HIV-1 and cytokine (IFN-gamma/TNF-alpha) synergy in CXCL10 release from astrocytes: Implications in HIV-Associated Dementia

Megan Gasparovic

The role of JC virus minor capsid proteins in the viral lifecycle

Clarisa Buckner

Transmigration of HIV-infected monocytes/macrophages and lymphocytes into the central nervous system

Rick Cheung

Signal transduction mechanisms of HIV-1 gp120-induced proinflammatory cytokine interleukin-1 beta (IL-1 beta) production by primary human macrophages

7:00 pm – 9:00 pm

Reception and Poster Session I

Presentation of all odd numbered posters