8:30 am – 10:05 am

Session IV

Antiviral therapy: Emerging modalities and CNS implications

Erik De Clercq
(Plenary Speaker)

In search of antivirals for the treatment of neurovirus infections

Ronald J. Ellis
(Plenary Speaker)

Efficacy of antiretroviral therapy in the brain

Vivek Nerurkar

Serotonin receptor 2A blocker (Risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells

Monique Lafon

Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis

Joseph Steiner

Paroxetine treatment of HIV-mediated neurodegeneration

10:05 am – 10:30 am

Coffee Break

10:30 am – 12:10 pm

Session V

Emerging concepts on viral effects on the nervous system: Viruses as discovery tools

W. Ian Lipkin
(Plenary Speaker)

Pathogen surveillance and discovery in acute and chronic disease

Paul Patterson

Activating the maternal immune system causes changes in the offspring resembling those in schizophrenia and autism

Susan R. Weiss

Inhibition of the IFN-alpha/beta response by mouse hepatitis virus (MHV) at multiple levels

Paola Grandi

Design of ICP0-deficient HSV oncolytic vectors for treatment of glioblastoma

Mikhail V. Pletnikov

Activation of microglia by a neurotropic RNA Borna Disease Virus is initiated by neuron-astrocyte interactions, leading to neurodegeneration

Elaine L. Bearer

Association of HSV and amyloid precursor protein during intraneuronal transport: A time-lapse live imaging study

12:10 pm - 12:45 pm

Neurological Infections Lectureship
Karen Roos

Advancements in the diagnosis and management of CNS bacterial, fungal and tuberculous infections

12:45 pm – 2:15 pm

Lunch

12:45 pm – 2:15 pm

Breakout Session II

International AIDS Research Update

12:45 pm – 2:15 pm

Breakout Session III

MS and Molecular Observations Workshop

Christopher Power

The human endogenous retrovirus envelope glycoprotein, Syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: A role for ER chaperones in astrocytes

Robert Fujinami

Infection of the CNS need not occur to get inflammatory changes within the brain

Herve Perron

A double-blind European multicenter study evidences envelope protein from human endogenous retrovirus W (MSRV-ENV or Syncytin) in serum from 73% of MS patients without selective clinical inclusion criteria

Antonina Dolei

Multiple sclerosis (MS)-associated retrovirus (MSRV) is inhibited during interferon-beta therapy of MS patients and behaves as progression biomarker

2:15 pm – 3:50 pm

Session VI

Stem cell biology, nanomedicine, and therapy

Micheline McCarthy
(Plenary Speaker)

Neurogenesis in the setting of chronic viral infection

Eugene Major
(Plenary Speaker)

Lineage directed differentiation of human brain derived progenitor cells alters JC Virus and HIV-1 fate of infection: Implications of neuropathogenesis

Ruth Brack-Werner

HIV persistence in neural progenitor populations

Jianlin Zheng

HIV-1-infected and/or immune-activated macrophages affect human fetal cortical neural progenitor cell proliferation and differentiation through TNF-alpha

3:50 pm – 4:15 pm

Coffee Break

4:15 pm – 5:45 pm

Investigators in Training II

Mamata Mishra

Clade specific variation in HIV-1 transactivating protein (Tat) induced neurotoxicity in human neurons

Georgina Perez-Liz

JC virus latency in the normal human brain

Caroline Soulas

Non SIV-infected MAC387+ macrophages accumulate within encephalitic lesions of SIV-infected rhesus monkeys: MAC387 as a potential marker of disease

Kelly Meulendyke

Effects of minocycline and PMPA on dopamine and dopamine metabolite levels in the caudate nucleus of SIV-infected pigtailed macaques

Anupam Banerjee

Regulation of CXCR4 expression and impact on HIV-1 infection by the mu-opiod agonist DAMGO in a bone marrow progenitor cell line model

Wei Kou

Astrocytic activation causes impaired glutamate clearance and altered CD38/cADPR signaling: Mechanistic links to HIV-1-Associated Dementia

7:00 pm – 9:00 pm

Reception and Poster Session II

Presentation of all even numbered posters