Optimizing Animal Models for Evolving HAND Phenotypes
and CNS Reservoir Research
Windsor Ballroom (Lower Level), The Omni King Edward Hotel
Toronto, Ontario, Canada | October 25th, 2016

The clinical and pathological aspects of the effects of HIV infection on the central nervous system (CNS) have changed. With the advent of antiretroviral therapy (ART), the spectrum of CNS disorders has changed. While HIV associated neurocognitive disorders (HAND) still affect a considerable proportion of people living with HIV (PLHIV), the signs and symptoms are in general milder, and HAND does not correlate with findings of HIV-related neuropathology.

Following an introduction to NeuroAIDS and Cure research, this afternoon session will feature an assessment of the current presentation of HAND as well as a review of its neuropathology. A number of the animal models will be presented, focusing on their utility for understanding HAND pathogenesis, its prevention and treatment, and applicability to eradication/cure studies, with a focus on translatability. A moderated open discussion will be used to stimulate communication and presentation of ideas from scientists in the field.

The agenda for this session can also be downloaded for printing and offline viewing.

This session
is independent event held in conjunction with the Conference and Symposium.

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Setting the Stage [Chair: Howard Fox, UNMC]

12:05 PM- 12:15 PM

Jeymohan Joseph, NIMH, NIH

Meeting Goals

12:15 PM- 12:30 PM

Ned Sacktor, Johns Hopkins School of Medicine

Changing clinical phenotypes of HAND

12:30 PM- 12:45 PM

Benjamin Gelman, University of Texas Medical Center

Neuropathology of HAND with Suppressive Antiretroviral Therapy

Rodent Models [Chair: Kelly Jordan- Sciutto, UPENN]

12:45 PM- 1:00 PM

Johnny He, University of North Texas Health Science Center

HIV-1 Tat Transgenic Mice

1:00 PM- 1:15 PM

Jay McLaughlin, University of Florida

Neurobehavioral Research in Tat Transgenic Mice

1:15 PM- 1:30 PM

Marcus Kaul, SBPMDI, La Jolla & UCSD, San Diego

HIV-1 gp120 transgenic Mice

1:30 PM- 1:45 PM

Walter Royal, University of Maryland Medical Center

The HIV-1 transgenic rat model of neuroHIV

1:45 PM- 2:00 PM

William Tyor, Emory University

HIV-1 Encephalitis Mouse model

BREAK [2:00 PM- 2:15 PM]

2:15 PM- 2:30 PM

David Volsky, Mount Sinai

Pathobiology of chronic HIV-cognitive impairment (HIV- NCI) in EcoHIV infected mice and preclinical testing of NCI therapeutics

2:30 PM - 2:45 PM

Alcino Jose Silva, UCLA

Molecular, cellular and circuit mechanisms underlying CCR5-dependent learning and memory deficits

2:45 PM - 3:00 PM

Chris Power, University of Alberta

Comparative lentivirus persistence in the CNS-therapeutic implications.

3:15 PM- 3:30 PM

Larisa Poluektova, University of Nebraska Medical Center

Immune system - Glia crosstalk and HIV-1 reservoir formation in dual blood and brain humanized mice.

3:30 PM- 3:45 PM

Jenna B. Honeycut, UNC Chapel Hill

Humanized mouse models for myeloid reservoir studies in the CNS (MOM Mice)

3:45 PM - 3:55 PM

Lena Al-Harthi, RUSH University

Human transplanted astrocytes into NSG-HuPBMCs mice demonstrate astrocyte-initiated HIV spread from the brain to other tissues

3:55 PM- 4:05 PM

Jonathan Karn, Case Western Reserve Univ.

A humanized mouse model for latent HIV infections of the CNS

BREAK [4:05 PM- 4:15 PM]

Primate Models [Chair: Shilpa Buch, UNMC]

4:15 PM- 4:30 PM

Joseph Mankowski, Johns Hopkins School of Medicine

A SIV Macaque Model for HIV-1 CNS Reservoir and NeuroAIDS research

4:30 PM- 4:45 PM

Ken Williams, Boston College

Accelerated SIV infected pigtailed monkey model for NeuroAIDS research

4:45 PM- 4:55 PM

Lishomwa Ndhlovu, University of Hawaii

Early CSF Viremia and CNS T Cell Infiltrate in a Non- Accelerated SHIV Infection Model

4:55 PM- 5:10 PM

Howard Fox, University of Nebraska Medical Center

Other Primate Models used in HIV-1 CNS Research

5:10 PM - 6:30 PM : Discussion [Chair: Howard Fox, UNMC]

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