7:30 am

Registration and Continental Breakfast (Vanity Fair Foyer and Pall Mall, Second Level)

ISNV Session 3: Viral latency (Vanity Fair Ballroom, Second Level)

Moderators: Maria Nagel and Randall Cohrs

8:30 am

Audrey Gilden Lectureship

Anne Gershon (Columbia University Medical Center, New York, NY, USA)

Prevention of varicella and zoster by immunization: is it worthwhile?

Introduction by Maria Nagel

9:00 am

Benjamin Gelman (University of Texas Medical Branch, Galveston, TX, USA)

Whole body mapping shows a relatively small pool of latent HIV in the CNS not strongly related to pools in other body compartments

9:15 am

Emma Wanicek (Burnet Institute, Melbourne, VIC, Australia)

Detection of HIV-1 DNA in brain tissue of virally suppressed patients supports the existence of a persistent CNS viral reservoir

9:30 am

Rafal Kaminski (Temple University, Philadelphia, PA, USA)

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

ISNV Session 4A: Neural injury and viral pathogenesis (Windsor Ballroom, Lower Level)

Moderators: Marcus Kaul and Dianne Langford

ISNV Session 4B: Demyelinating disease pathogenesis (Vanity Fair Ballroom, Second Level)

Moderators: Walter Royal and Pasquale Ferrante

9:45 am

Ken Tyler (University of Colorado School of Medicine, Aurora, CO, USA)

A new polio? Enterovirus D-68 and acute flaccid myelitis

9:45 am

Lloyd Kasper (Dartmouth Geisel School of Medicine, Lebanon, NH, USA)

In the garden of good and evil: The gut microbiome and CNS demyelinating disease

10:15 am

Santhi Gorantla (University of Nebraska Medical Center, Omaha, NE, USA)

Autophagy Facilitates Nanoformulated antiretroviral Drug Depots for Sustained Release and Enhanced Anti-Retroviral Activity

10:15 am

Ninella Dolei (University of Sassari, Sassari, Italy)

JC polyomavirus expression and bell-shaped regulation of its SF2/ASF suppressor in multiple sclerosis patients under therapy with Natalizumab

10:30 am

Joe Steiner (National Institutes of Health, Bethesda, MD, USA)

Development of an inducible cell line screening for therapeutic antagonists to HIV Tat protein

10:30 am

Herve Perron (Geneuro-Innovation, Lyon, France)

HERV-W envelope expression in microglia from Multiple Sclerosis patients: a lifelong role in neuroinflammation, demyelination and axonal lesion

10:45 am

Pooja Jain (Drexel University, Philadelphia, PA, USA)

Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity

11:00 am

Morning Break (Vanity Fair Lobby, Second Level)

ISNV Session 5: Investigators-in-Training (Part I) (Vanity Fair Ballroom, Second Level)

Moderators: Jay Rappaport and Lena Al-Harthi

11:20 am

Bianca Cotto (Temple University, Philadelphia, PA, USA)

Microglial activation and cocaine addiction

11:35 am

Use of a lip scarification mouse model to study the pathology, immunology, and virology associated HSV-1 Infection of the periphery and corresponding trigeminal ganglia

11:50 am

Robert Roscoe (University of South Carolina, Columbia, SC, USA)

Increased oral self-administration of methylphenidate and decreased dopamine release in the nucleus accumbens core region of HIV-1 transgenic rats

12:05 pm

Courtney Veilleux (Rutgers University, Newark, NJ, USA)

Characterization of Zika virus infection in Human Astrocytes

12:20 pm

Lunch Break and Networking (talks resume at 1:50 pm)

ISNV Session 6: Animal models in neurovirology (Vanity Fair Ballroom, Second Level)

Moderators: Joseph Mankowski and Jennifer Gordon

1:50 pm

Guido Silvestri (Emory University School of Medicine, Atlanta, GA, USA)

Animal models for HIV cure research

2:20 pm

Siddappa Byrareddy (University of Nebraska Medical Center, Omaha, NE, USA)

Macrophage-tropic Simian Immunodeficiency Virus Molecular Clone causes NeuroAIDS in Rhesus Macaques

2:35 pm

Ravi Mahalingam (University of Colorado, Denver, Aurora, CO, USA)

Simian varicella virus reactivates in rhesus macaques after depletion of CD4 T cells

2:50 pm

Won-Bin Young (University of Pittsburgh, Pittsburgh, PA, USA)

In vivo visualization of HIV transmission and viremia rebound in humanized mice

Women in Neuroscience Lectureship (Vanity Fair Ballroom, Second Level)

Moderators: Joan Berman and Mahendra Kumar

3:05 pm

Shilpa Buch (University of Nebraska Medical Center, Omaha, NE, USA)

From NeuroAIDS to HAND: Trials, Tribulations and Hope

Introduction by Joan Berman

3:35 pm

Afternoon Break (Vanity Fair Foyer)

ISNV Session 7: Investigators-in-Training (Part II) (Vanity Fair Ballroom, Second Level)

Moderators: Ruth Brack-Werner and Walter Royal

3:55 pm

Effects of flaxseed lignin, Secoisolariciresinol diglucose, on endogenous antioxidant pathway in HIV-infected macrophages

4:10 pm

Astrocyte-shed extracellular vesicles regulate synchronous network burst activity

4:25 pm

Varicella zoster virus downregulates PD-L1 and MHC-1 in human brain vascular adventitial fibroblasts, perineurial cells and lung fibroblasts

4:40 pm

Development of a humanized astrocyte/human peripheral blood mononuclear cells NOD/scid-IL-2Rgc null mouse model to assess the role of astrocytes in HIV infection

ISNV Session 8: New NIH Office of AIDS Research Guidelines (Vanity Fair Ballroom, Second Level)

4:55 pm

Woody Lin (National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA)

NIH OAR HIV/AIDS research priority guidelines

5:15 pm

Eduardo Montalvo (Center for Scientific Review, National Institutes of Health, Bethesda, MD, USA)

Update from the Center for Scientific Review

5:35 pm

Discussion

6:30 pm

Poster Session (Windsor Ballroom, Lower Level)