7:30 am

Registration and Continental Breakfast (Vanity Fair Foyer and Pall Mall, Second Level)

ISNV Session 9: Systemic infections and the use of addictive substances (Vanity Fair Ballroom, Second Level)

Moderators: Sulie Chang and Rosemarie Booze

8:30 am

Introductory Remarks

Rosemarie Booze (University of South Carolina, Columbia, SC, USA)

8:35 am

Xuebin Qin (Temple University, Philadelphia, PA, USA)

The hCD59 transgenic rodent model of Intermedilysin-mediated cell ablation

9:05 am

Jennifer Kelschenbach (Icahn School of Medicine at Mount Sinai, New York, NY, USA)

Chronic morphine administration exacerbates EcoHIV-induced neurocognitive impairments in mice

9:20 am

Prasun Datta (Temple University, Philadelphia, PA, USA)

Macrophage OXPHOS regulation by HIV-1 Vpr and cocaine

9:35 am

Svetlana Semenova (University of California San Diego, La Jolla, CA, USA)

HIV-1 TAT protein expression enhances methamphetamine behavioral sensitization and alters dopaminergic function in mice

ISNV Session 10: The rising threat of Zika virus (Vanity Fair Ballroom, Second Level)

Moderator: Lynn Pulliam

9:50 am

J. David Beckham (University of Colorado School of Medicine, Aurora, USA)

New insights into flavivirus pathogenesis with the emergence of Zika virus

10:20 am

Arnold Kriegstein (University of California, San Francisco, San Francisco, CA USA)

Zika virus in the developing brain: Cell tropism and drug inhibition

10:50 am

Morning Break (Vanity Fair Foyer)

ISNV Session 11: Emerging viral pathogens (Vanity Fair Ballroom, Second Level)

Moderator: Igor Koralnik

11:05 am

Bridgette Billioux (National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA)

Neurological manifestations and sequelae in Ebola virus disease

11:35 am

Avindra Nath (National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA)

Endogenous retrovirus as a cause of Motor Neuron Disease

12:05 pm

Lunch Break and Networking (talks resume at 1:35 pm)

12:05 pm

ISNV Board of Directors Meeting (Belgravia Room, Second Level)

ISNV Session 12: Special topics in neurovirology (Vanity Fair Ballroom, Second Level)

Moderators: Tricia Burdo and Mahmut Safak

1:35 pm

Madhavan Nair (Florida International University, Miami, FL, USA)

Getting into the brain: Potential of nanotechnology to manage neuro-AIDS and drug addictions

1:50 pm

Sandra Skuja (Rīga Stradins University, Riga, Latvia)

Assessing the correlation between the grey and white matter damage and HHV-6 involvement in the frontal and temporal lobes of the brain of the elderly

2:05 pm

Pankaj Seth (National Brain Research Centre, Manesar, India)

Novel molecular pathway of perturbation of ATP release in astrocytes contributes to neuronal death in HAND

2:20 pm

Lisa Magnus (Johns Hopkins University, Baltimore, MD, USA)

A CNS IRIS-like phenotype in SIV-infected pigtailed macaques on cART

ISNV Session 13: NeuroAIDS NRSA (T32) Trainee Research (Vanity Fair Ballroom, Second Level)

Moderators: David Stoff, Jay Rappaport, and Brian Wigdahl

2:35 pm

Introductory Remarks

David Stoff (National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA)

2:40 pm

Research Training in NeuroVirology: Supporting Pathways to Success

Panel Discussion led by David Stoff and Deborah Colosi

3:05 pm

Mike Veenstra (Albert Einstein College of Medicine, Bronx, NY, USA)

JAM-A and ALCAM Mediate Preferential Transmigration Across the BBB of HIV-infected HIV+CD14+CD16+ Monocytes: Continued Viral Seeding of the CNS and HAND

3:20 pm

Shibani S. Mukerji (Dana-Farber Cancer Institute, Boston, MA, USA)

Cerebrospinal Fluid Viral Escape in ART-experienced HIV-1-Infected Adults

3:35 pm

Neil Sullivan (Drexel University, Philadelphia, PA, USA)

Clinical and functional characterization of viral single nucleotide polymorphisms (SNPs) within the HIV-1 LTR associate with increased virus persistence in the Drexel Medicine CARES Cohort

3:50 pm

Afternoon Break (Vanity Fair Foyer)

Richard Johnson Lectureship (Vanity Fair Ballroom, Second Level)

4:10 pm

Justin McArthur (Johns Hopkins University, Baltimore, MD, USA)

NeuroAIDS: remaining challenges in an era of virological control

Introduction by Avindra Nath

ISNV Session 14: Chronic immune activation (Vanity Fair Ballroom, Second Level)

Moderators: James Lokensgard and Tracy Fischer

4:40 pm

Dorian McGavern (National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA)

Mechanisms underlying non-cytopathic control of CNS viral infections

5:10 pm

Norm Haughey (Johns Hopkins University, Baltimore, MD, USA)

Informatic interrogation of CSF proteomic profiles from HIV-infected subjects implicates acute phase and complement systems in shifting cognitive status

5:25 pm

Jay Rappaport (Temple University, Philadelphia, PA, USA)

Investigating the kynurenine pathway in SIV/HIV infection: Potential target for immune modulation and treatment of comorbid conditions

5:40 pm

Closing remarks (Vanity Fair Ballroom, Second Level)

7:00 pm

Pioneer Reception (Lobby Lounge, Lobby Level)

8:00 pm

ISNV Pioneer in NeuroVirology Gala Dinner (Sovereign Ballroom, Lobby Level)