Biotypes of CNS Complications in People Living with HIV Meeting October 21-22, 2021

Central Nervous System (CNS) complications are highly prevalent, heterogeneous conditions among people living with HIV (PWH) on modern suppressive antiretroviral therapy (ART). The underlying pathophysiology of these CNS complications remains elusive, and no effective therapies exist to slow, stop, or reverse the adverse outcomes that can persist despite virological suppression. Despite multiple efforts to remediate these CNS disease outcomes associated with HIV, there has been limited success due to heterogeneity of etiologies and presentation. In addition, multiple comorbidities (e.g., substance use disorders, cardiovascular disease) as well as social and structural determinants of health (e.g., environmental factors, stigma, trauma) can also affect the CNS outcomes. These issues of heterogeneity are not just limited to HIV associated CNS disease outcomes but have been challenging for several other neuropsychiatric conditions. Thus, the field experiencing a paradigm shift in neuropsychiatry towards integration of psychiatry with the neurosciences to identify biotypes linked with psychopathology.
This proposed series of workgroup meetings will bring together the leading experts in the NeuroHIV field, to identify and analyze common data elements from the different HIV associated CNS disease studies by integrating elements of underlying psychopathology with the currently available measures such as self-report, neuropsychological testing, neuroimaging, and plasma/CSF biomarker analyses. These efforts in combination with novel approaches that integrate multi-dimensional data and tools such as AI based learning algorithms can help the field ascertain Biotypes/ clusters that are based on psychopathology. This workgroup effort will aid in significantly advancing our understanding of the basic and clinical neuroscience of HIV associated CNS complications.
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Previous Conferences

The primary goal of the Indo-US Symposium on Viral Infections of the Nervous System is to bring together pioneers in the field of Neurovirology from US and India to a single platform, to nurture their research ideas as well as to explore potential collaborations in areas of mutual interests. The symposium aims to provide young investigators working in the field of Neurovirology and related areas with cutting edge information so that important gaps in knowledge can be identified and interesting avenues for future research are explored. This meeting would involve 50-60 basic researchers, clinical scientists, students and trainees working in the diverse areas of neurology, neuropathology, neuropathogenesis, neurobiology, neuroimmunology, neurochemistry and molecular virology of the CNS.
Click here to download a meeting flyer.

The Clinical and Diagnostic Topics on CNS and Inflammation Workshop, on October 12th, 2010 in Milan, Italy, will precede the opening of the 10th International Symposium on NeuroVirology and 2010 Conference on HIV in the Nervous System. This Workshop will focus on the most intriguing and challenging topics in the field of CNS inflammatory diseases.

The International Neuroinfectious Disease Conference, sponsored in part by the ISNV, was held in Addis Ababa, Ethiopia, on February 27-28, 2010. The meeting covered topics relevant to neuroinfectious diseases and conditions prevalent in Africa, including HIV/AIDS, neuroAIDS, tuberculosis, cerebral malaria, bacterial meningitis, and viral encephalitis.