Detailed Agenda - 11th International Symposium on Neurovirology

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Thursday, 31 May

7:00 am - 8:00 am

Continental Breakfast

8:00 am - 9:15 am

Session V

Chronic immune reactivation and leukocyte trafficking

    Session Chairs: Joan Berman and Jay Rappaport
8:00 am
Steven D. Douglas (Plenary)
The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
The neurokinin-1 receptor and substance P: Modulation of HIV/SIV immune reactivation and leukocyte trafficking
8:30 am
Donald Gilden
University of Colorado Denver School of Medicine, Aurora, CO, USA
The immune repertoire in varicella zoster virus (VZV) vasculopathy and its association with VZV-induced cerebrovascular remodeling
8:45 am
Georgette Kanmogne
University of Nebraska Medical Center, Omaha, NE, USA
HIV-1 induces cytoskeletal alteration and reorganization during endothelial-monocyte interactions: Modulatory role of CCR5
9:00 am
Yuri Persidsky
Temple University School of Medicine, Philadelphia, PA, USA
Inhibition of poly(ADP-ribose) polymerase (PARP)-1 protects blood brain barrier in HIV CNS infection

9:15 am - 9:45 am

Special Lecture

2012 Paradigm Builder Lectureship

    Introduction by David Volsky
  Michael G. Katze
University of Washington, Seattle, WA, USA
Systems biology as a new approach for comprehensive studies of viral pathogenesis – But where are Google and IBM?

9:45 am - 10:05 am

Coffee Break


10:05 am - 11:20 am

Special Activity

Investigators-in-Training (Part I)

    Session Chairs: Walter Royal, III, and Ruth Brack-Werner
10:05 am
Stephanie James
Postdoctoral Fellow, University of Colorado School of Medicine, Aurora, CO, USA
VZV infection of human brain vascular adventitial fibroblasts down-regulates STAT mRNA expression and inhibits translocation of pSTAT to the nucleus
10:20 am
Laura Ellis
Graduate Student, Beth Israel Deaconess Medical Center, Boston, MA, USA
Role of agnogene deletion and archetype-like regulatory region in a JCV strain isolated from the brain of a patient with JCV Encephalopathy (JCVE)
10:35 am
Matthew Cusick
Postdoctoral Fellow, University of Utah, Salt Lake City, UT, USA
Macrophage infiltration of the brain in Theiler’s virus infection contributes to the development of seizures
10:50 am
Amrita Datta Chaudhuri
Graduate Student, University of Nebraska Medical Center, Omaha, NE, USA
Up-regulation of neuronal microRNA-142 in HIVE/SIVE leads to a decrease in monoamine oxidase A expression and activity by inhibiting SIRT1
11:05 am
Sarah Berth
Graduate Student, University of Illinois Chicago, Chicago, IL, USA
The HIV glycoprotein gp120 impairs fast axonal transport through an axon-autonomous mechanism

11:20 am - 12:35 pm

Session VI

Immunopathogenesis of viral infections

    Session Chairs: Shilpa Buch and Carlos Pardo
11:20 am
Robert F. Siliciano (Plenary)
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
New insights into highly active antiretroviral therapy for HIV infection: How HAART really works
11:50 am
Glenn Rall
Fox Chase Cancer Center, Philadelphia, PA, USA
Distinct interferon responses in neurons may contribute to survival during viral infection
12:05 pm
Monique Anderson
National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA
Characterization and behavior of T regulatory cells in HTLV-1 associated myelopathy / tropical spastic paraparesis
12:20 pm
Yamil Gerena
University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Secretion of soluble insulin receptor from human neuronal cells exposed to the cerebrospinal fluid from HIV-seropositive women correlates with cognitive performance

12:35 pm - 2:10 pm

Lunch Break / Networking


12:35 pm - 2:10 pm

ISNV Board of Directors Meeting

Majestic Board Room


2:10 pm - 6:00 pm

Poster Set-up

Empire State Ballroom IV-V


2:10 pm - 3:25 pm

Workshop I

Uris and Juilliard Rooms

Intersection of substance abuse and HIV in the CNS
    Session Chairs: Diane Lawrence and Roger Sorensen
    Panel discussions on topic areas related to substance abuse and HIV (Igor Grant, Brian Wigdahl, Avindra Nath, Joan Berman, Kurt Hauser, Shilpa Buch)
2:10 pm
NIDA Staff Workshop Overview
2:15 pm

Panel A
(led by Joan Berman)

Regulation of glial function and inflammation
Jacqueline Coley
Albert Einstein College of Medicine, Bronx, NY, USA
Dopamine mediated changes in blood-brain barrier and neuroinflammation in the context of CNS HIV infection and substance abuse
Myosotys Rodriguez-Martinez
Universidad del Valle School of Medicine, Cali, Columbia
Methadone and buprenorphine modulation on HIV-1 infection, inflammation, and neurotoxicity
Santosh Kumar
University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA
Central role of cytochrome P450 2A6 in tobacco-mediated oxidative stress in macrophages and astrocytes
2:35 pm
Panel B
(led by Avindra Nath)
Molecular signaling in the CNS
Paula Desplats
University of California, San Diego, San Diego, CA, USA
Effects of methamphetamine on the epigenetic regulation of HIV-1 in the human brain
Joyce Velez
University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Cocaine and marijuana alter lipidomics in HAND
Jonathan Pitcher
Drexel University College of Medicine, Philadelphia, PA, USA
Elevated ferritin heavy chain and dysregulated CXCL12/CXCR4 signaling within cortical neurons of drug abusers and HIV+ individuals
Erick Tatro
University of California San Diego, San Diego, CA, USA
MicroRNA-9 is increased in CNS neurons in the HIV-infected brain and in methamphetamine exposure
2:55 pm
Panel C
(led by Igor Grant)
Behavioral outcomes of HIV and substance use
Erica Weber
University of California, San Diego, San Diego, CA, USA
Methamphetamine use exacerbates HIV-associated neurocognitive impairment in acute and early HIV infection
Brook Henry
University of California San Diego, San Diego, CA, USA
A Tale of Mice and Men: Translational cross-species assessment of inhibitory deficits in HIV and comorbid methamphetamine dependence using a novel human open-field paradigm
Svetlana Semenova University of California, San Diego, San Diego, CA, USA Expression of HIV gp120 protein increases sensitivity to the rewarding properties of methamphetamine in mice
3:15 pm
Wrap Up / Future Directions  

2:10 pm - 3:25 pm

Workshop II

Broadway Room

Demyelinating disease pathogenesis (including multiple sclerosis) and polyomaviruses

    Session Chairs: Robert Fujinami and Walter Royal, III
2:10 pm
Emily Leibovitch
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
HHV-6A infection enhances EAE severity in the common marmoset
2:35 pm
Elodie Brison
INRS-Institut Armand-Frappier, Laval, Quebec, Canada
Glutamate excitotoxicity is involved in motor dysfunction and paralysis following infection by a human respiratory corona virus
2:50 pm
Alejandra Borjabad
St. Lukes-Roosevelt Hospital Center, Columbia University, New York, NY, USA
Common transcriptional signatures in HIV-1-Associated Neurocognitive Disorder, Alzheimer’s Disease, and Multiple Sclerosis: Comparison with a mouse model of HAND
3:05 pm
Armine Darbinyan
Temple University School of Medicine, Philadelphia, PA, USA
Polyomavirus JC infection of human oligodendrocyte progenitor cells dysregulates production of chemokines and alters differentiation of oligodendrocytes

3:25 pm - 3:45 pm

Coffee Break


3:45 pm - 5:00 pm

Session VII

Neural injury and neurorestoration

    Session Chairs: Lena Al-Harthi and Dennis Kolson
3:45 pm
Marcus Kaul (Plenary)
Sanford-Burnham Medical Research Institute, La Jolla, CA, USA
To prevent or repair HIV-associated brain injury
4:15 pm
Eliseo Eugenin
University of Medicine and Dentistry, New Jersey - New Jersey Medical School, Newark, NJ, USA
Identification of intracellular toxic signals required for bystander killing through gap junctions from HIV-infected astrocytes to uninfected astrocytes
4:30 pm
Jennifer Gordon
Temple University School of Medicine, Philadelphia, PA, USA
The impact of HIV-1 Tat on Pur-alpha mediated regulation of dendritic RhoA signaling
4:45 pm
Andrew Levine
National Neurological AIDS Bank, Los Angeles, CA, USA
Longitudinal analysis of interactive effects of host genotype, stimulant use, and HIV status upon neurocognitive functioning

6:00 pm - 9:00 pm

Poster Session / Reception

Empire State Ballroom IV-V and Foyer


Shading indicates presentations associated specifically with the 2012 Conference on HIV in the Nervous System

Thursday, 31 May